Disclaimer: Aside from the House of Bread and Peace (and that was a donation of things not money), I haven't donated to any of these charities. I looked them all up online and looked up a site that rates them. They all had high ratings, but I do want you to know that I haven't actually donated through them.
House of Bread and Peace: Woman and Children's Shelter
If you're in Evansville, this is a shelter for women and children. I don't know tons about it, but I met a woman who worked there at my kids' santa shop this December and she made a really positive impression on me. She was caring, but down-to-earth. And the House of Bread and Peace accepts lots of kinds of donations--food, clothes, toys, etc. They can be used or not. The food can be homemade or not. http://sites.google.com/site/houseofbreadandpeace/
I seem to have a thing for the sponsor-a-child ones because they tended to draw my interest. I believe that the ones below you can sponsor a person or donate.
Plan USA
This is a charity where you can "adopt" a child for $25/month. http://www.planusa.org/
Save the Children
To donate, click here. If you want more info, click their icon on the donation page and you'll go to their home page.
Compassion International
Home page here
Pearl S. Buck International
Home page here
Children Incorporated
Home page here
Christian Foundation for Children and Aging
Home page here
Bread for the World Institute
Home page here
Feed the Children
Home page here
Child Fund International
Home page here
World Vision
Home page here